Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Bissau (96% of total searches to Guinea-Bissau). The next most popular destinations are Mansôa (2%) and Bubaque (1%). Searches for hotels in Rubane Island (1%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Guinea-Bissau is Bissau. Bolama and Oio are also very popular.
KAYAK users have found double rooms in Guinea-Bissau for as cheap as $41 (Bissau) in the last 3 days. The average price is $146.